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Globalization | Type 2 Diabetes Pandemic in Developing Countries

Written by The Informed Aussie
Published on Thursday, February 9th, 2012
Globalist Report

In the past few decades, the socioeconomic conditions of nations around the world have trended towards parity, and there has been a growth of global interdependencies. This continuing trend poses various risks to individual nations ranging from political unrest, loss of cultural expression and the increased incidence of certain diseases.

In this article, we examine Type 2 Diabetes, one of this decade’s greatest pandemics (World Diabetes Foundation, 2006).  Specifically, we aim to look at the role of socioeconomic predictors of this disease in developing and developed nations.

TYPE 2 DIABETES

What is it?

Type 2 Diabetes is an illness involving the pancreas producing inadequate levels of insulin, or the body’s insufficient response to the insulin that it produces (World Health Organization, 2008). Long term complications may include blindness, heart disease, kidney problems, nerve damage, and erectile dysfunction (Canadian Diabetes Association, 2008). In 2006, the United Nations officially recognized diabetes as a global health threat (Canadian Diabetes Association, 2008).

Etiology

Research is being conducted to better understand the biochemical pathways involved in the development of Type 2 Diabetes. Some studies have shown that insulin-receptor substrates (IRS proteins), specifically IRS-2, may be linked with Type 2 Diabetes (Withers et al., 1998). Moreover, some researchers have been using novel experimental techniques with magnetic resonance spectroscopy (MRS) in order to provide insight into molecular defects present in diabetic subjects.

Based on this research, it is observed that insulin resistance observed in diabetics is mainly attributed to reduced activity of insulin-stimulated glucose transport via the GLUT4 protein (Petersen & Shulman, 2006). Although the exact cause of Type 2 Diabetes is still unknown, healthcare professionals agree that it is the result of both genetic factors and lifestyle. Physical inactivity and obesity are often cited as the main causes, indicating that this disease may be  preventable to some extent (Bennett, 1998).

GLOBAL EPIDIMIOLOGY

Overview

While considered a disease of affluence, diabetes is now becoming increasingly prevalent in developing countries (Siegel & Narayan, 2008). Diabetes affects 5.9% of the world’s adult population, and accounts for approximately 5% of all global deaths, showing that it truly is a disease of global proportions (Figure 1). The number of deaths is expected to increase by more than 50% in the next 10 years.

Several interesting trends arise as public health professionals and epidemiologists attempt to analyse morbidity data. For example, 80% of people with diabetes worldwide live in low and middle-income countries. While the rate of obesity among these countries is lower than high income countries, it is expected that low and middle-income countries will experience the greatest increase in prevalence.

This indicates that there could possibly be a causal relationship between a country’s socioeconomic status and the prevalence of diabetes. Furthermore, the age distribution of sufferers differs greatly: most people with diabetes in low and middle-income countries are middle-aged (45-64), unlike high income countries, where most diabetic patients are elderly

World map showing diabetes prevalence as percent of population

Developing countries have higher absolute morbidity and faster projected growth rates of absolute morbidity

Diabetes Prevalence, 2025 vs. GDP PPP per capita

Figure 3

(65+) (World Health Organization, 2008). This acts as further evidence of a possible link between wealth and diabetes (Figure 2). However, it should be noted that this data could simply be a reflection of life expectancy differences among countries.

The possibility of a connection between a country’s socioeconomic status and the risk of Type 2 Diabetes has not been fully understood. In order to examine this possibility, we investigated the effect of gross domestic product at purchasing power parity (GDP PPP) per capita, an indicator of socioeconomic status on diabetes prevalence (Figures 3). Diabetes prevalence estimates from the year 2000 and predictions for the year 2025 were used, in order to see current and future trends (King et al. 1998). GDP PPP per capita data was obtained from the year 2007, as this was the most complete and reliable data set available (Central Intelligence Agency, 2008). To further analyze these trends, we examined the relationship between GDP PPP per capita and the estimated increase in diabetes prevalence from 2000-2025.

Analysis

There appears to be a trend of increase in diabetes prevalence by GDP PPP per capita with a pronounced peak around $6000 – $10 000. While it appears that a relationship exists, the significance of such a relationship is limited, as the comparison is between only the GDP PPP per capita figures. Since this data is used at a national level, it may not be assumed that all members of these countries will face increased risk of diabetes. Instead, it is more appropriate to look at this potential connection holistically, considering other factors within nations that could explain the increase in diabetes prevalence.

Many behavioural risk factors for Type 2 Diabetes are characteristic of the lifestyles of industrialized countries. Thus, developed countries have a high prevalence of this illness. Since Type 2 Diabetes affects an older population and these countries are generally aging, the frequency of the disease will continue to increase.

As developing countries are becoming wealthier and increasingly interdependent on developed countries, diabetes risk factors characteristic of developed countries may be starting to affect developing countries as well. The availability and marketing of lipidrich and processed foods, time-saving gadgets, occupational reforms and urbanization are likely contributing towards the increase of diabetes prevalence seen in developing countries (Siegel & Narayan, 2008).

Implications of the Diabetes Pandemic

The diabetes pandemic is very costly for all countries; direct medical costs are approximately five times higher for diabetics than the general population. These high costs are causing a great strain on national and individual spending in many poorer nations. Countries afflicted may see a drop in productivity, which will lead to a lower quality of life for its citizens (Siegel & Narayan, 2008).

CONCLUSION

Our analysis shows that there may be a connection between a socioeconomic indicator – GDP PPP per capita and diabetes prevalence of diabetes. While there is no simple or direct correlation between the two variables, overall trends indicate that greater increases in diabetes prevalence will occur in rapidly developing countries. These countries will experience the greatest burden of diabetes over the next two decades, as they will be forced to reform healthcare systems to deal with a rapidly changing morbidity profile.

The exposure of diabetes in medical literature and the media has significantly increased in recent times, although several misconceptions still surround the illness. Some believe that it is a completely preventable disease, while others feel that current treatment methods are adequate and do not support investing into better cures and long-term solutions. Nonetheless, Type 2 Diabetes is a serious, chronic illness which severely affects the quality of life of those who suffer from it. Estimates of increases in diabetes prevalence over the next twenty years are astounding and drastic changes to public health policy are crucial to better manage this pandemic.

 
Written by Neil Dattani and Allan Jiang (2009)
The Meducator: Vol. 1: Iss. 15, Article 7.
 

Cited Sources

  1. Bennett, P.H. (1998). Etiology and Determinants of Type 2 Diabetes Mellitus. [Powerpoint slides]. Retrieved September 18, 2008 from http://www.pitt.edu/~super1/lecture/lec0461/index.htm
  2. Canadian Diabetes Association. (2008). About diabetes. Retrieved September 17, 2008 from http://www.diabetes.ca/aboutdiabetes/what/
  3. Central Intelligence Agency. (2008). The World Factbook. Retrieved September 22, 2008 from https://www.cia.gov/library/publications/the-world-factbook/index.html
  4. King, H, Aubert, R.E., & Herman, W.H. (1998). Global Burden of Diabetes, 1995-2025. Diabetes Care, 21(9), 1414-1431.
  5. Novo Nordisk Care. (2008). Type 2 Diabetes. Retrieved September 15, 2008 from http://www.novonordiskcare.com/type-2-diabetes/
  6. Petersen, K.F., & Shulman, G.I. (2006). Etiology of Insulin Resistance. The American Journal of Medicine, 119(1), S10-S16.
  7. Siegel, K., & Narayan, K.M.V. (2008). The Unite for Diabetes campaign: Overcoming constraints to find a global policy solution. Global Health, 4(3).
  8. Wild, S., Roglic, G., & Green, A. (2004). Global Prevalence of Diabetes. Diabetes Care, 27(5), 1047-1053.
  9. Withers, D.J., Gutierrez, J.S., Towery, H., Burks, D., Ren, J.M., Previs, S. et al. (1998). Disruption of IRS-2 causes type 2 diabetes in mice. Nature, 391(6670), 900-904.
  10. World Diabetes Foundation. (2006). Diabetes facts. Retrieved September 15, 2008 from http://www.worlddiabetesfoundation.org/composite-35.htm
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  • http://www.facebook.com/profile.php?id=100002428500911 Dolores Schroepfer

    Actually, the min culprit causing type 2 diabetes is high fructose corn syrup. Just yesterday I read a study that found that this product, which is in virtually all processed foods, is the primary cause. People in countries that have this product available in foods are at extreme risk for type 2 diabetes. Additionally, high fructose corn syrup contains extreme amounts of chemical toxins due to the process used in manufacturing it. The one thing that you can do to help those you love is to be gin researching HFCS and pass the information on to everyone you know. Additionally, it is as addictive as heroin, so once people begin to eat it they crave ever more of it. NEVER, EVER allow your children to eat anything that contains HFCS. READ labels on every product you intend to purchase. You will be shocked to find HFCS in virtually every processed food.
    Lastly, I will say this…….it is not by accident that this product has been put into our food supply . It is as dangerous as tobacco, heroin, crack, or any street drug you can find.
    I work in the field of health care.

    • http://www.theglobalistreport.com/ Andrew Puhanic

      Hi Dolores, thanks for your comments… I agree with what you have said.

      Whether it’s the fluoride in our water or the GM food we eat, it is becoming increasingly difficult to avoid these nasty government byproducts.

      I worry not only for the future of our children, but also for the future of our childrens children.

  • Dana

    This is quite disturbing news! I don’t know what we can do to improve the situation. Maybe we and our governments should invest more in research and health care rather than in all kinds of corporate products…

  • jeff

    oh the joys of democracy! cleverly hidden by corpocracy.